Drug Information
Drug General Information | |||||
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Drug ID |
D0SB6Y
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Former ID |
DNC013560
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Drug Name |
D-211A
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529287] | ||
Structure |
Download2D MOL |
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Formula |
C29H33FN2O
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Canonical SMILES |
C1CC(N2CCN(C1C2)CCC(C3=CC=C(C=C3)F)O)C(C4=CC=CC=C4)C5=C<br />C=CC=C5
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InChI |
1S/C29H33FN2O/c30-25-13-11-22(12-14-25)28(33)17-18-31-19-20-32-21-26(31)15-16-27(32)29(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,26-29,33H,15-21H2/t26-,27-,28+/m0/s1
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InChIKey |
GAKAYJNKCDLKCE-HZFUHODCSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Sodium-dependent serotonin transporter | Target Info | Inhibitor | [529287] | |
Sodium-dependent dopamine transporter | Target Info | Inhibitor | [529287] | ||
Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [529287] | ||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | 5HT1 type receptor mediated signaling pathway | ||||
5HT2 type receptor mediated signaling pathway | |||||
5HT3 type receptor mediated signaling pathway | |||||
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis | |||||
Parkinson disease | |||||
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis | |||||
Pathway Interaction Database | Alpha-synuclein signaling | ||||
WikiPathways | Monoamine Transport | ||||
SIDS Susceptibility Pathways | |||||
NRF2 pathway | |||||
Synaptic Vesicle Pathway | |||||
Serotonin Transporter ActivityWP727:Monoamine Transport | |||||
Dopaminergic Neurogenesis | |||||
Parkinsons Disease Pathway | |||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport | |||||
References | |||||
Ref 529287 | Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. Epub 2008 Jan 11.Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. | ||||
Ref 529287 | Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. Epub 2008 Jan 11.Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. |
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