Drug Information

Drug General Information
Drug ID
D0Y3TZ
Former ID
DNC007143
Drug Name
GALLICACID
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540931]
Structure
Download
2D MOL

3D MOL
Formula
C7H6O5
InChI
InChI=1S/C7H6O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,8-10H,(H,11,12)
InChIKey
LNTHITQWFMADLM-UHFFFAOYSA-N
PubChem Compound ID
370
PubChem Substance ID
4609, 82806, 93480, 515619, 597137, 623400, 841193, 3139303, 6189885, 8001876, 8145227, 8150599, 10508685, 11341578, 11361761, 11363236, 11365798, 11368360, 11371268, 11375146, 11376522, 11484353, 11487163, 11488215, 11490070, 11493358, 11494156, 11537513, 12015396, 15219485, 17389871, 24438743, 24864730, 24895304, 25623933, 26613118, 26679367, 26747307, 26747308, 29204161, 47291482, 47589331, 48110832, 48413806, 48423452, 48425162, 49855037, 50105531, 50626002, 53787072
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [530751]
Carbonic anhydrase IV Target Info Inhibitor [530751]
Carbonic anhydrase I Target Info Inhibitor [530751]
Carbonic anhydrase XIV Target Info Inhibitor [530751]
Carbonic anhydrase VI Target Info Inhibitor [530751]
P-selectin Target Info Inhibitor [528676]
Carbonic anhydrase IX Target Info Inhibitor [530751]
Carbonic anhydrase XII Target Info Inhibitor [530751]
Carbonic anhydrase II Target Info Inhibitor [530751]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa04514:Cell adhesion molecules (CAMs)
Malaria
Staphylococcus aureus infectionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database C-MYB transcription factor networkil4_2pathway:IL4-mediated signaling events
amb2 Integrin signalinghif1_tfpathway:HIF-1-alpha transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-114608:Platelet degranulation
Cell surface interactions at the vascular wallR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon DioxideWP2806:Human Complement System
Spinal Cord Injury
Cell surface interactions at the vascular wallWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 540931(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5549).
Ref 528676J Med Chem. 2007 Mar 22;50(6):1101-15. Epub 2007 Feb 16.Rational design of novel, potent small molecule pan-selectin antagonists.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.

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