Drug General Information
Drug ID
D06OKE
Former ID
DNC007471
Drug Name
MCL-433
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528655]
Structure
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2D MOL

3D MOL

Formula
C19H26N2O2
Canonical SMILES
CNC(=O)OC1=CC2=C(CC3C4C2(CCCC4)CCN3C)C=C1
InChI
1S/C19H26N2O2/c1-20-18(22)23-14-7-6-13-11-17-15-5-3-4-8-19(15,16(13)12-14)9-10-21(17)2/h6-7,12,15,17H,3-5,8-11H2,1-2H3,(H,20,22)
InChIKey
YJGQAUOQIDQXIT-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [528655]
Delta-type opioid receptor Target Info Inhibitor [528655]
Kappa-type opioid receptor Target Info Inhibitor [528655]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathway
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 528655Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. Epub 2007 Jan 17.High-affinity carbamate analogues of morphinan at opioid receptors.
Ref 528655Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. Epub 2007 Jan 17.High-affinity carbamate analogues of morphinan at opioid receptors.

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