| Drug General Information |
| Drug ID |
D01SZX
|
| Former ID |
DNC010872
|
| Drug Name |
1-Imidazol-1-ylmethylxanthen-9-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H12N2O2
|
| Canonical SMILES |
C1=CC=C2C(=C1)C(=O)C3=C(C=CC=C3O2)CN4C=CN=C4
|
| InChI |
1S/C17H12N2O2/c20-17-13-5-1-2-6-14(13)21-15-7-3-4-12(16(15)17)10-19-9-8-18-11-19/h1-9,11H,10H2
|
| InChIKey |
FJYGKMHQKKRCON-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
17 alpha-hydroxylase-C17, 20-lyase |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Glucocorticoid biosynthesis
|
|
Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
|
|
Estradiol biosynthesis II
|
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Estradiol biosynthesis I
|
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KEGG Pathway
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Steroid hormone biosynthesis
|
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Metabolic pathways
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Ovarian steroidogenesis
|
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Prolactin signaling pathwayhsa00140:Steroid hormone biosynthesis
|
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NetPath Pathway
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FSH Signaling Pathway
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PANTHER Pathway
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Androgen/estrogene/progesterone biosynthesis
|
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PathWhiz Pathway
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Androgen and Estrogen Metabolism
|
|
SteroidogenesisPW000045:Androgen and Estrogen Metabolism
|
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Reactome
|
Androgen biosynthesis
|
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Glucocorticoid biosynthesis
|
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Endogenous sterolsR-HSA-211976:Endogenous sterols
|
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WikiPathways
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Metapathway biotransformation
|
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Steroid Biosynthesis
|
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Oxidation by Cytochrome P450
|
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Metabolism of steroid hormones and vitamin D
|
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Glucocorticoid & Mineralcorticoid Metabolism
|
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Prostate Cancer
|
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Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
|
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Tryptophan metabolism
|
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Ovarian Infertility Genes
|
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FSH signaling pathway
|
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Integrated Breast Cancer Pathway
|
|
Phase 1 - Functionalization of compounds
|
| References |
| REF 1 | Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. doi: 10.1021/jm100319h. |
|---|
