Drug General Information
Drug ID	D08RCQ
Former ID	DNC013855
Drug Name	5-(4-Methoxyphenyl)-4-p-tolylisothiazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529881]
Structure		Download 2D MOL 3D MOL
Formula	C17H15NOS
Canonical SMILES	CC1=CC=C(C=C1)C2=C(SN=C2)C3=CC=C(C=C3)OC
InChI	1S/C17H15NOS/c1-12-3-5-13(6-4-12)16-11-18-20-17(16)14-7-9-15(19-2)10-8-14/h3-11H,1-2H3
InChIKey	KPYJYWIFJYUIBB-UHFFFAOYSA-N
PubChem Compound ID	44564416
Target and Pathway
Target(s)	Prostaglandin G/H synthase 1	Target Info	Inhibitor	[529881]
BioCyc Pathway	C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
	Serotonergic synapse
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 529881	Bioorg Med Chem. 2009 Jan 15;17(2):558-68. Epub 2008 Dec 6.Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.
Ref 529881	Bioorg Med Chem. 2009 Jan 15;17(2):558-68. Epub 2008 Dec 6.Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.

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