Drug Information

Drug General Information
Drug ID
D0P7AS
Former ID
DNC009671
Drug Name
5-Fluoro-6-ethyluridine-5'-O-monophosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529995]
Structure
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2D MOL

3D MOL
Formula
C11H16FN2O9P
Canonical SMILES
CCC1=C(C(=O)NC(=O)N1C2C(C(C(O2)COP(=O)(O)O)O)O)F
InChI
1S/C11H16FN2O9P/c1-2-4-6(12)9(17)13-11(18)14(4)10-8(16)7(15)5(23-10)3-22-24(19,20)21/h5,7-8,10,15-16H,2-3H2,1H3,(H,13,17,18)(H2,19,20,21)/t5-,7-,8-,10-/m1/s1
InChIKey
JBBLQWFDKGRNST-VPCXQMTMSA-N
PubChem Compound ID
25027092
Target and Pathway
Target(s) Orotidine 5'-monophosphate decarboxylase Target Info Inhibitor [529995]
BioCyc Pathway Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine ribonucleotides de novo biosynthesis
UMP biosynthesis
KEGG Pathway Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 529995J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
Ref 529995J Med Chem. 2009 Mar 26;52(6):1648-58.Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.

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