Drug Information

Drug General Information
Drug ID
D06YMS
Former ID
DNC000511
Drug Name
DADLE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538983]
Structure
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2D MOL

3D MOL
Formula
C29H39N5O7
InChI
InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1
InChIKey
ZHUJMSMQIPIPTF-IBURTVSXSA-N
PubChem Compound ID
6917707
PubChem Substance ID
12012839, 14788692, 14813091, 17194510, 43529138, 49689098, 57371657, 75592831, 103356943, 114786819, 134339921, 134344643, 135650156, 135697931, 136259340, 137156937, 162221179, 236343594, 241113750, 241376633, 249617978, 252157533, 252350756
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [535092]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538983(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1607).
Ref 535092Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle. J Am Coll Cardiol. 2000 Dec;36(7):2296-302.

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