Drug Information

Drug General Information
Drug ID
D0G8ZD
Former ID
DNC012736
Drug Name
(1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535513]
Structure
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2D MOL

3D MOL
Formula
C22H19N3
Canonical SMILES
CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4
InChI
1S/C22H19N3/c1-16(17-10-4-2-5-11-17)23-22-19-14-8-9-15-20(19)24-21(25-22)18-12-6-3-7-13-18/h2-16H,1H3,(H,23,24,25)/t16-/m1/s1
InChIKey
AEXWSMVZORVWML-MRXNPFEDSA-N
PubChem Compound ID
1564645
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Inhibitor [535513]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 535513Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8.
Ref 535513Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8.

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