TTD | Drug: D0L5OU

Drug General Information
Drug ID	D0L5OU
Former ID	DIB018132
Drug Name	[11C]xanomeline
Synonyms	[11C]xanomeline (PET ligand)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540241]
Structure		Download 2D MOL
Formula	C14H23N3OS
InChI	InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3/i2-1
InChIKey	JOLJIIDDOBNFHW-JVVVGQRLSA-N
PubChem Compound ID	73755040
PubChem Substance ID	178100319
Target and Pathway
Target(s)	Muscarinic receptor	Target Info	Agonist	[534227]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540241	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3278).
Ref 534227	PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man. Dementia. 1996 Jul-Aug;7(4):187-95.

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Drug Information