Drug Information

Drug General Information
Drug ID
D0E4YP
Former ID
DNC001285
Drug Name
SB 227122
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534953]
Structure
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2D MOL

3D MOL
Formula
C33H39IN2O2
Canonical SMILES
CC1=CC=C(C=C1)C2=CC3=C(CCCC(=C3)C(=O)NC4=CC=C(C=C4)C[N+<br />](C)(C)C5CCOCC5)C=C2.[I-]
InChI
1S/C33H38N2O2.HI/c1-24-7-11-27(12-8-24)28-14-13-26-5-4-6-29(22-30(26)21-28)33(36)34-31-15-9-25(10-16-31)23-35(2,3)32-17-19-37-20-18-32;/h7-16,21-22,32H,4-6,17-20,23H2,1-3H3;1H
InChIKey
AYXBAIULRDEVAS-UHFFFAOYSA-N
CAS Number
CAS 229005-80-5
PubChem Compound ID
9873888
PubChem Substance ID
14838863, 24163700, 45296145, 78425978, 103255445, 103987228, 134340491, 225080281, 229084847
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [534953]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 534953The antitussive activity of delta-opioid receptor stimulation in guinea pigs. J Pharmacol Exp Ther. 2000 Feb;292(2):803-9.
Ref 534953The antitussive activity of delta-opioid receptor stimulation in guinea pigs. J Pharmacol Exp Ther. 2000 Feb;292(2):803-9.

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