Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05RQB
|
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| Former ID |
DNC000238
|
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| Drug Name |
Aphidicolin
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Discontinued in Phase 1 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H34O4
|
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| Canonical SMILES |
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
|
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| InChI |
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13?,14?,15?,16-,17+,18+,19?,20+/m1/s1
|
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| InChIKey |
NOFOAYPPHIUXJR-NPNXGXLRSA-N
|
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| CAS Number |
CAS 38966-21-1
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA polymerase (HSV-2) | Target Info | Inhibitor | [2], [3] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002516) | ||||
| REF 2 | Proteasome regulation of ULBP1 transcription. J Immunol. 2009 May 15;182(10):6600-9. | ||||
| REF 3 | Characterization of an aphidicolin-resistant mutant of herpes simplex virus type 2 which induces an altered viral DNA polymerase. Virology. 1984 May;135(1):87-96. | ||||
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