Drug General Information
Drug ID	D04REX
Former ID	DNC005628
Drug Name	5-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyrimidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527456]
Structure		Download 2D MOL 3D MOL
Formula	C14H11FN2
Canonical SMILES	C1CC(=CC2=CN=CN=C2)C3=C1C=C(C=C3)F
InChI	1S/C14H11FN2/c15-13-3-4-14-11(1-2-12(14)6-13)5-10-7-16-9-17-8-10/h3-9H,1-2H2/b11-5-
InChIKey	LEJPKWXGQFBXRX-WZUFQYTHSA-N
PubChem Compound ID	6539808
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[527456]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compounds
References
Ref 527456	J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
Ref 527456	J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

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