| Drug General Information |
| Drug ID |
D08QBU
|
| Former ID |
DNC007712
|
| Drug Name |
1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C27H31NO
|
| Canonical SMILES |
C1CN(CCC1(CCCC2=CC=CC=C2)O)C(C3=CC=CC=C3)C4=CC=CC=C4
|
| InChI |
1S/C27H31NO/c29-27(18-10-13-23-11-4-1-5-12-23)19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-9,11-12,14-17,26,29H,10,13,18-22H2
|
| InChIKey |
LBCGIDHKEKGBGS-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Delta-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Mu-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Nociceptin receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
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Estrogen signaling pathway
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Morphine addictionhsa04080:Neuroactive ligand-receptor interaction
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Pathway Interaction Database
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IL4-mediated signaling events
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Reactome
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Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling events
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WikiPathways
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signalingWP69:TCR Signaling Pathway
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Opioid Signalling
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GPCR downstream signaling
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| References |
| REF 1 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. |
|---|
