Drug Information

Drug General Information
Drug ID
D01WMU
Former ID
DNC007504
Drug Name
1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528785]
Structure
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2D MOL

3D MOL
Formula
C26H29NO
Canonical SMILES
CC1=CC=CC=C1C(C2=CC=CC=C2C)N3CCC(CC3)(C4=CC=CC=C4)O
InChI
1S/C26H29NO/c1-20-10-6-8-14-23(20)25(24-15-9-7-11-21(24)2)27-18-16-26(28,17-19-27)22-12-4-3-5-13-22/h3-15,25,28H,16-19H2,1-2H3
InChIKey
MHYKPRJMOSXVFG-UHFFFAOYSA-N
PubChem Compound ID
9820782
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Inhibitor [528785]
Kappa-type opioid receptor Target Info Inhibitor [528785]
Mu-type opioid receptor Target Info Inhibitor [528785]
Nociceptin receptor Target Info Inhibitor [528785]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP69:TCR Signaling Pathway
Opioid Signalling
GPCR downstream signaling
References
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.

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