Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05HVY
|
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| Former ID |
DCL000826
|
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| Drug Name |
GSK-644784
|
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| Drug Type |
Small molecular drug
|
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| Indication | Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] | Discontinued in Phase 2 | [536374] | ||
| Therapeutic Class |
Analgesics
|
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| Company |
GlaxoSmithKline
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C24H36F3N5O7
|
||||
| Canonical SMILES |
CCC(CO)NCCNC(CC)CO.C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=<br />CC=C(C=C3)OC(F)(F)F
|
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| InChI |
1S/C14H12F3N3O5.C10H24N2O2/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11;1-3-9(7-13)11-5-6-12-10(4-2)8-14/h1-4,6,11H,5,7-8H2;9-14H,3-8H2,1-2H3/t11-;9-,10-/m00/s1
|
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| InChIKey |
CSKKOIQIXPTXLB-MZEPSHEKSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 2 | Target Info | Inhibitor | [536374] | |
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| NF-kappa B signaling pathway | |||||
| VEGF signaling pathway | |||||
| TNF signaling pathway | |||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Leishmaniasis | |||||
| Pathways in cancer | |||||
| Chemical carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| Small cell lung cancer | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
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