Drug Information

Drug General Information
Drug ID
D0KA0M
Former ID
DNC001450
Drug Name
TIPP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534987]
Structure
Download
2D MOL

3D MOL
Formula
C37H38N4O6
Canonical SMILES
C1C(N(CC2=CC=CC=C21)C(=O)C(CC3=CC=C(C=C3)O)N)C(=O)NC(CC<br />4=CC=CC=C4)C(=O)NC(CC5=CC=CC=C5)C(=O)O
InChI
1S/C37H38N4O6/c38-30(19-26-15-17-29(42)18-16-26)36(45)41-23-28-14-8-7-13-27(28)22-33(41)35(44)39-31(20-24-9-3-1-4-10-24)34(43)40-32(37(46)47)21-25-11-5-2-6-12-25/h1-18,30-33,42H,19-23,38H2,(H,39,44)(H,40,43)(H,46,47)/t30-,31-,32-,33-/m0/s1
InChIKey
JYOUATXRHWNDDW-YRCZKMHPSA-N
CAS Number
CAS 269055-15-4
PubChem Compound ID
644210
PubChem Substance ID
841870, 8707314, 14989084, 43765917, 57408224, 75511693, 103463433, 103962856, 104141093, 109827776, 134340632, 134351333, 135076584
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Antagonist [534987]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 534987The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers. 1999;51(6):411-25.
Ref 534987The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers. 1999;51(6):411-25.

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