Drug Information

Drug General Information
Drug ID
D06ELD
Former ID
DNC007259
Drug Name
WIN_35428
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467847]
Formula
C16H20FNO2
InChI
InChI=1S/C16H20FNO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3/t12-,13+,14+,15-/m0/s1
InChIKey
QUSLQENMLDRCTO-YJNKXOJESA-N
PubChem Compound ID
105056
PubChem Substance ID
841221, 7980893, 10233746, 15592186, 15999163, 44434591, 48256938, 49846212, 50070295, 50070955, 80857297, 99381459, 103830466, 104373526, 135061515, 136923382, 137005050, 162224472, 163409699, 163847606, 172854647, 178101325, 178101326, 184598330, 189053169, 223564571, 223739720, 227768658, 243808150, 250229889, 252498738
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [534240]
Sodium-dependent dopamine transporter Target Info Inhibitor [534240]
Sodium-dependent serotonin transporter Target Info Inhibitor [534240]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 467847(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4606).
Ref 534240J Med Chem. 1996 Oct 11;39(21):4139-41.3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.

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