Drug Information

Drug General Information
Drug ID
D0J0ES
Former ID
DNC012732
Drug Name
1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527062]
Structure
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2D MOL

3D MOL
Formula
C19H21Cl2NO
Canonical SMILES
CCN(CC)C1CC(C2=C1C=C(C=C2)O)C3=CC(=C(C=C3)Cl)Cl
InChI
1S/C19H21Cl2NO/c1-3-22(4-2)19-11-15(12-5-8-17(20)18(21)9-12)14-7-6-13(23)10-16(14)19/h5-10,15,19,23H,3-4,11H2,1-2H3
InChIKey
NIIGXDSCJHJWSY-UHFFFAOYSA-N
PubChem Compound ID
44322661
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [527062]
Sodium-dependent dopamine transporter Target Info Inhibitor [527062]
Sodium-dependent serotonin transporter Target Info Inhibitor [527062]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 527062J Med Chem. 2004 May 6;47(10):2624-34.Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
Ref 527062J Med Chem. 2004 May 6;47(10):2624-34.Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.

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