| Drug General Information |
| Drug ID |
D0I1YH
|
| Former ID |
DNC011029
|
| Drug Name |
4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H15NO
|
| Canonical SMILES |
C1=CC(=CC(=C1)O)C2=CC=C(C=C2)CC3=CC=NC=C3
|
| InChI |
1S/C18H15NO/c20-18-3-1-2-17(13-18)16-6-4-14(5-7-16)12-15-8-10-19-11-9-15/h1-11,13,20H,12H2
|
| InChIKey |
GFIBJCSJSOCGMM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 11B1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|---|
| 17 alpha-hydroxylase-C17, 20-lyase |
Target Info |
Inhibitor |
[1]
|
| Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Glucocorticoid biosynthesis
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Mineralocorticoid biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
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Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
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Estradiol biosynthesis II
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Estradiol biosynthesis I
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KEGG Pathway
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Steroid hormone biosynthesis
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Metabolic pathwayshsa00140:Steroid hormone biosynthesis
|
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Metabolic pathways
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Ovarian steroidogenesis
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Prolactin signaling pathwayhsa00140:Steroid hormone biosynthesis
|
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NetPath Pathway
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FSH Signaling Pathway
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PANTHER Pathway
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Androgen/estrogene/progesterone biosynthesis
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PathWhiz Pathway
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SteroidogenesisPW000045:Androgen and Estrogen Metabolism
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Reactome
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Glucocorticoid biosynthesis
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Endogenous sterolsR-HSA-193048:Androgen biosynthesis
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Endogenous sterolsR-HSA-211976:Endogenous sterols
|
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WikiPathways
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Metapathway biotransformation
|
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Oxidation by Cytochrome P450
|
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Metabolism of steroid hormones and vitamin D
|
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Corticotropin-releasing hormoneWP702:Metapathway biotransformation
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Steroid Biosynthesis
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Glucocorticoid & Mineralcorticoid Metabolism
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Prostate Cancer
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Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
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Tryptophan metabolism
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Ovarian Infertility Genes
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FSH signaling pathway
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Integrated Breast Cancer Pathway
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Phase 1 - Functionalization of compounds
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| References |
| REF 1 | J Med Chem. 2010 Aug 12;53(15):5749-58.Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. |
|---|
