Drug General Information
Drug ID	D00RNA
Former ID	DNC008112
Drug Name	N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529102]
Structure		Download 2D MOL 3D MOL
Formula	C12H11NO4
Canonical SMILES	C1=CC=C2C(=C1)C=C(C(=O)O2)CCC(=O)NO
InChI	1S/C12H11NO4/c14-11(13-16)6-5-9-7-8-3-1-2-4-10(8)17-12(9)15/h1-4,7,16H,5-6H2,(H,13,14)
InChIKey	HJRCGMHZQDXQAO-UHFFFAOYSA-N
PubChem Compound ID	44446270
Target and Pathway
Target(s)	72 kDa type IV collagenase	Target Info	Inhibitor	[529102]
	MMP-9	Target Info	Inhibitor	[529102]
	ADAM 17	Target Info	Inhibitor	[529102]
KEGG Pathway	Leukocyte transendothelial migration
	GnRH signaling pathway
	Estrogen signaling pathway
	Pathways in cancer
	Proteoglycans in cancer
	Bladder cancerhsa04668:TNF signaling pathway
	Hepatitis B
	Transcriptional misregulation in cancer
	MicroRNAs in cancer
	Bladder cancerhsa04330:Notch signaling pathway
	Alzheimer's disease
	Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway	Leptin Signaling Pathway
	TCR Signaling Pathway
	ID Signaling PathwayNetPath_5:ID Signaling Pathway
	TWEAK Signaling Pathway
	TNFalpha Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
	CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
	Alzheimer disease-presenilin pathway
	Notch signaling pathway
Pathway Interaction Database	LPA receptor mediated events
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Direct p53 effectors
	amb2 Integrin signaling
	ATF-2 transcription factor network
	FOXM1 transcription factor network
	Regulation of nuclear beta catenin signaling and target gene transcription
	Syndecan-2-mediated signaling eventslysophospholipid_pathway:LPA receptor mediated events
	Validated targets of C-MYC transcriptional activation
	CXCR4-mediated signaling events
	Syndecan-4-mediated signaling events
	AP-1 transcription factor network
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Syndecan-1-mediated signaling events
	FGF signaling pathwayerbb4_pathway:ErbB4 signaling events
	TNF receptor signaling pathway
	p75(NTR)-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
	Assembly of collagen fibrils and other multimeric structures
	EPH-ephrin mediated repulsion of cellsR-HSA-1251985:Nuclear signaling by ERBB4
	Regulated proteolysis of p75NTR
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 t(7
	M1580_K2555) Translocation Mutant
	Constitutive Signaling by NOTCH1 HD Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	TNF signaling
	Growth hormone receptor signaling
WikiPathways	Activation of Matrix Metalloproteinases
	AGE/RAGE pathway
	Matrix MetalloproteinasesWP474:Endochondral Ossification
	IL1 and megakaryotyces in obesity
	Mammary gland development pathway - Involution (Stage 4 of 4)
	Degradation of collagen
	Spinal Cord Injury
	TWEAK Signaling Pathway
	Angiogenesis
	Osteopontin Signaling
	Matrix MetalloproteinasesWP61:Notch Signaling Pathway
	Copper homeostasis
	Notch Signaling Pathway
	Growth hormone receptor signaling
	BDNF signaling pathway
	Alzheimers Disease
	Signalling by NGF
	Extrinsic Pathway for Apoptosis
References
Ref 529102	Bioorg Med Chem. 2008 Jan 1;16(1):530-5. Epub 2007 Sep 14.Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation.
Ref 529102	Bioorg Med Chem. 2008 Jan 1;16(1):530-5. Epub 2007 Sep 14.Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.