Target Information
Target General Infomation | |||||
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Target ID |
T52382
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Former ID |
TTDR00927
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Target Name |
Lymphocyte antigen 96
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Gene Name |
LY96
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Synonyms |
ESOP-1; MD-2; MD-2 protein; LY96
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Target Type |
Research
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Function |
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
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UniProt ID | |||||
Sequence |
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGL
LHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFS FKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN |
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Pathways | |||||
KEGG Pathway | NF-kappa B signaling pathway | ||||
Toll-like receptor signaling pathway | |||||
Pathogenic Escherichia coli infection | |||||
Pertussis | |||||
Toxoplasmosis | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
IL6 Signaling Pathway | |||||
PANTHER Pathway | Toll receptor signaling pathway | ||||
Pathway Interaction Database | Endogenous TLR signaling | ||||
Reactome | Ligand-dependent caspase activation | ||||
Toll Like Receptor 4 (TLR4) Cascade | |||||
Mal cascade initiated on plasma membrane | |||||
MyD88-independent TLR3/TLR4 cascade | |||||
TRIF-mediated programmed cell death | |||||
MyD88 deficiency (TLR2/4) | |||||
IRAK4 deficiency (TLR2/4) | |||||
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||||
IKK complex recruitment mediated by RIP1 | |||||
TRAF6 mediated induction of TAK1 complex | |||||
WikiPathways | Toll-like receptor signaling pathway | ||||
Toll-Like Receptors Cascades | |||||
Mal cascade initiated on plasma membrane | |||||
MyD88-independent cascade | |||||
Pathogenic Escherichia coli infection | |||||
Regulation of toll-like receptor signaling pathway | |||||
References |
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