Target General Infomation
Target ID
T52382
Former ID
TTDR00927
Target Name
Lymphocyte antigen 96
Gene Name
LY96
Synonyms
ESOP-1; MD-2; MD-2 protein; LY96
Target Type
Research
Function
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
UniProt ID
Sequence
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGL
LHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFS
FKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
Inhibitor 3-Hydroxy-Myristic Acid Drug Info [551393]
Lauric Acid Drug Info [551393]
MYRISTIC ACID Drug Info [551374]
Pathways
KEGG Pathway NF-kappa B signaling pathway
Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Pertussis
Toxoplasmosis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL6 Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signaling
Reactome Ligand-dependent caspase activation
Toll Like Receptor 4 (TLR4) Cascade
Mal cascade initiated on plasma membrane
MyD88-independent TLR3/TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complex
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
Mal cascade initiated on plasma membrane
MyD88-independent cascade
Pathogenic Escherichia coli infection
Regulation of toll-like receptor signaling pathway
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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