Target Information
Target General Infomation | |||||
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Target ID |
T14582
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Former ID |
TTDR00158
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Target Name |
Alanine racemase,biosynthetic
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Gene Name |
alr
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Synonyms |
AlaR; Alanine racemase; Alr; D-alanine racemase; alr
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Target Type |
Research
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Function |
Catalyzes the interconversion of L-alanine and D- alanine. Overexpression due to a natural mutation in the promoter is responsible for mediating resistance to D-cycloserine (DCS) in mycobacteria.
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BioChemical Class |
Racemases and epimerases
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UniProt ID | |||||
EC Number |
EC 5.1.1.1
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Sequence |
MQTTEPMTPPAPLASAQTVIDLGAIDHNVRVLRELAGSADVMAVVKADAYGHGALPVART
ALAAGAAALGVATIPEALALREGGITAPVLAWLHPPGTDFAPAIAADVEVAVSSRRQLEQ VTAAAAEVGRTATVTVKVDTGLSRNGVGAADYPEVLDVLRRAQADGAIRVRGLMSHLVHG DDPENPFNGLQGQRLADMRVYAREHGVDYEVAHLCNSPAAMTRPDLAFEMVRPGISLYGL SPIPERGDMGLRPAMTLKCPVALVRSVHAGDGVSYGHRWVADRDTTLGLLPIGYADGVYR ALSGRIDVLIKGRRRRAVGRICMDQFVVDLGPDADDVAVGDDAILFGPGANGEPTAQDWA ELLDTIHYEVVTSPRGRVTRTYLPAGQQD |
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Inhibitor | (R)-4-Amino-Isoxazolidin-3-One | Drug Info | [551393] | ||
3-fluorovinylglycine | Drug Info | [537262] | |||
Acetate Ion | Drug Info | [551393] | |||
Lysine Nz-Carboxylic Acid | Drug Info | [551393] | |||
N-(5'-Phosphopyridoxyl)-D-Alanine | Drug Info | [551393] | |||
Propanoic Acid | Drug Info | [551393] | |||
Propionate | Drug Info | [535842] | |||
Pyridoxamine-5'-Phosphate | Drug Info | [551393] | |||
Pyridoxyl-Alanine-5-Phosphate | Drug Info | [551393] | |||
Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate | Drug Info | [551393] | |||
References |
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