Target Information
Target General Infomation | |||||
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Target ID |
T75517
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Former ID |
TTDR00774
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Target Name |
GMP synthase [glutamine-hydrolyzing]
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Gene Name |
GMPS
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Synonyms |
GMP synthetase; Glutamine amidotransferase; GMPS
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Target Type |
Research
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Function |
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
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BioChemical Class |
Carbon-nitrogen ligase
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UniProt ID | |||||
EC Number |
EC 6.3.5.2
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Sequence |
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE |
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Pathways | |||||
BioCyc Pathway | Guanosine nucleotides de novo biosynthesis | ||||
Superpathway of purine nucleotide salvage | |||||
Purine nucleotides de novo biosynthesis | |||||
Guanosine ribonucleotides de novo biosynthesis | |||||
KEGG Pathway | Purine metabolism | ||||
Drug metabolism - other enzymes | |||||
Metabolic pathways | |||||
PANTHER Pathway | De novo purine biosynthesis | ||||
PathWhiz Pathway | Glutamate Metabolism | ||||
Purine Metabolism | |||||
Reactome | Purine ribonucleoside monophosphate biosynthesis | ||||
WikiPathways | Metabolism of nucleotides | ||||
References | |||||
Ref 537947 | High-level production from a baculovirus expression system and biochemical characterization of human GMP synthetase. Protein Expr Purif. 1995 Aug;6(4):487-95. |
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