Target Information
Target General Infomation | |||||
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Target ID |
T81100
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Former ID |
TTDC00336
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Target Name |
mRNA of sodium-glucosetransporter-2
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Gene Name |
SLC5A2
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Synonyms |
mRNA of Low affinity sodium-glucose cotransporter; mRNA of Na(+)/glucose cotransporter 2; mRNA of SGLT2; mRNA of SLC5A2; mRNA of Sodium/glucosecotransporter 2; mRNA of Solute carrierfamily 5 member 2; SLC5A2
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Target Type |
Clinical Trial
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Disease | Type 2 diabetes [ICD9: 250; ICD10: E11] | ||||
Function |
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
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BioChemical Class |
Solute:sodium symporter
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Target Validation |
T81100
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UniProt ID | |||||
Sequence |
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM MAVAVFLWGFYA |
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Drugs and Mode of Action | |||||
Inhibitor | 10-methoxy-N(1)-methylburnamine-17-O-veratrate | Drug Info | [530756] | ||
ACEROGENIN B | Drug Info | [530603] | |||
Acerogenin C | Drug Info | [530603] | |||
Alstiphyllanine D | Drug Info | [530756] | |||
Alstiphyllanine E | Drug Info | [530756] | |||
Alstiphyllanine F | Drug Info | [530756] | |||
Burnamine-17-O-3',4',5'-trimethoxybenzoate | Drug Info | [530756] | |||
FORMONONETIN | Drug Info | [528742] | |||
KURAIDIN | Drug Info | [528742] | |||
KURARINONE | Drug Info | [528742] | |||
Kushenol N | Drug Info | [528742] | |||
MAACKIAIN | Drug Info | [528742] | |||
O-spiroketal glucoside | Drug Info | [530988] | |||
SERGLIFLOZIN A | Drug Info | [530750] | |||
Sophoraflavanone G | Drug Info | [528742] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
References | |||||
Ref 528742 | Bioorg Med Chem. 2007 May 15;15(10):3445-9. Epub 2007 Mar 12.Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. | ||||
Ref 530603 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4. Epub 2009 Dec 11.Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. | ||||
Ref 530750 | Bioorg Med Chem. 2010 Mar 15;18(6):2178-94. Epub 2010 Feb 4.Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners. | ||||
Ref 530756 | Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. |
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