Drug Information

Drug General Information
Drug ID
D00HFT
Former ID
DNC010482
Drug Name
10-methoxy-N(1)-methylburnamine-17-O-veratrate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530756]
Structure
Download
2D MOL

3D MOL
Formula
C32H36N2O8
Canonical SMILES
CC=C1CN2C3CC1C(C45C3(N(C6=C4C=C(C=C6)OC)C)OC2C5)(COC(=O<br />)C7=CC(=C(C=C7)OC)OC)C(=O)OC
InChI
1S/C32H36N2O8/c1-7-18-16-34-26-14-21(18)30(29(36)40-6,17-41-28(35)19-8-11-24(38-4)25(12-19)39-5)31-15-27(34)42-32(26,31)33(2)23-10-9-20(37-3)13-22(23)31/h7-13,21,26-27H,14-17H2,1-6H3/b18-7-/t21-,26-,27-,30-,31-,32-/m0/s1
InChIKey
DTINADCHYFZWSG-BUVDGYSPSA-N
PubChem Compound ID
46229075
Target and Pathway
Target(s) mRNA of sodium-glucosetransporter-2 Target Info Inhibitor [530756]
Sodium/glucose cotransporter 1 Target Info Inhibitor [530756]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP2884:NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydrates
References
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.

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