Target Information
Target General Infomation | |||||
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Target ID |
T19433
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Former ID |
TTDS00192
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Target Name |
Glutathione S-transferase
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Gene Name |
HPGDS
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Synonyms |
GST class-alpha; Glutathione-S-transferase; HPGDS
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Target Type |
Successful
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Disease | Allergy [ICD9: 995.3; ICD10: T78.4] | ||||
Alzheimer disease [ICD9: 331; ICD10: G30] | |||||
Flatworms infection [ICD9: 120-129; ICD10: B65-B83] | |||||
Function |
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a widerange of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
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BioChemical Class |
Intramolecular oxidoreductases
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Target Validation |
T19433
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UniProt ID | |||||
EC Number |
EC 2.5.1.18
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Sequence |
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK VQAIPAVANWIKRRPQTKL |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
BioCyc Pathway | C20 prostanoid biosynthesis | ||||
KEGG Pathway | Arachidonic acid metabolism | ||||
Metabolic pathways | |||||
WikiPathways | Arachidonic acid metabolism | ||||
Aryl Hydrocarbon Receptor | |||||
Integrated Pancreatic Cancer Pathway | |||||
References | |||||
Ref 528089 | Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17. | ||||
Ref 536040 | Purification and catalytic properties of glutathione transferase from the hepatopancreas of crayfish macrobrachium vollenhovenii (herklots). J Biochem Mol Toxicol. 2004;18(6):332-44. | ||||
Ref 536194 | X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005Mar 1;61(Pt 3):263-5. Epub 2005 Feb 24. | ||||
Ref 536585 | Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic benefits. Parasitol Res. 2008 Mar;102(4):805-7. Epub 2008 Jan 5. | ||||
Ref 537154 | A novel method for screening the glutathione transferase inhibitors. BMC Biochem. 2009 Mar 16;10:6. |
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