Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N6JF
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| Former ID |
DIB001931
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| Drug Name |
H-PGDS inhibitors
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| Synonyms |
Hematopoietic prostaglandin D2 synthase inhibitors, Taiho; Prostanoid antagonists, Taiho; H-PGDS inhibitors (oral, allergy/inflammation); H-PGDS inhibitors (oral, allergy/inflammation), Taiho
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| Indication | Allergy [ICD9: 995.3; ICD10:T78.4] | Investigative | [1] | ||
| Company |
Taiho Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C1CCCN1C(=O)c1oc(c(c2nc3cc(C(=O)c4ccccc4)ccc3[nH]2)c1C)<br />C
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| Target and Pathway | |||||
| Target(s) | Glutathione S-transferase | Target Info | Antagonist | [2] | |
| BioCyc Pathway | C20 prostanoid biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| WikiPathways | Arachidonic acid metabolism | ||||
| Aryl Hydrocarbon Receptor | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| References | |||||
| REF 1 | Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis. Eur J Pharmacol. 2011 Sep 30;667(1-3):389-95 | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1381). | ||||
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