Drug Information

Drug General Information
Drug ID
D0Z6BY
Former ID
DNC006980
Drug Name
JWH-243
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528355]
Structure
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2D MOL

3D MOL
Formula
C27H27NO2
Canonical SMILES
CCCCCN1C=C(C=C1C2=CC=C(C=C2)OC)C(=O)C3=CC=CC4=CC=CC=C43
InChI
1S/C27H27NO2/c1-3-4-7-17-28-19-22(18-26(28)21-13-15-23(30-2)16-14-21)27(29)25-12-8-10-20-9-5-6-11-24(20)25/h5-6,8-16,18-19H,3-4,7,17H2,1-2H3
InChIKey
IQIAZANEJACDNJ-UHFFFAOYSA-N
PubChem Compound ID
44418354
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [528355]
Cannabinoid receptor 1 Target Info Inhibitor [528355]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.

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