| Drug General Information |
| Drug ID |
D0Z5RQ
|
| Former ID |
DNC009504
|
| Drug Name |
CREMASTRINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H25NO3
|
| Canonical SMILES |
CCC(C)C(C(=O)OCC1CCN2C1CCC2)O
|
| InChI |
1S/C14H25NO3/c1-3-10(2)13(16)14(17)18-9-11-6-8-15-7-4-5-12(11)15/h10-13,16H,3-9H2,1-2H3/t10-,11-,12+,13-/m1/s1
|
| InChIKey |
AVBKRVFZNFJQBK-FVCCEPFGSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M4 |
Target Info |
Inhibitor |
[1]
|
|---|
| Muscarinic acetylcholine receptor M5 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
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Regulation of actin cytoskeleton
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Insulin secretion
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Salivary secretion
|
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Gastric acid secretion
|
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Pancreatic secretionhsa04020:Calcium signaling pathway
|
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cAMP signaling pathway
|
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PI3K-Akt signaling pathway
|
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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PathWhiz Pathway
|
Gastric Acid Production
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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Acetylcholine regulates insulin secretion
|
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G alpha (q) signalling events
|
|
WikiPathways
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Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
|
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Regulation of Actin Cytoskeleton
|
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GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
|
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GPCR downstream signalingWP58:Monoamine GPCRs
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Integration of energy metabolism
|
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
|
|
Secretion of Hydrochloric Acid in Parietal Cells
|
| References |
| REF 1 | J Nat Prod. 2005 Apr;68(4):572-3.Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. |
|---|
