Drug Information

Drug General Information
Drug ID
D0Z3TJ
Former ID
DIB019947
Drug Name
GSK2033
Synonyms
GSK 2033; GSK-2033
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543247]
Structure
Download
2D MOL
Formula
C29H28F3NO5S2
InChI
InChI=1S/C29H28F3NO5S2/c1-19-14-20(2)28(21(3)15-19)40(36,37)33(18-25-12-13-27(38-25)29(30,31)32)17-22-8-10-23(11-9-22)24-6-5-7-26(16-24)39(4,34)35/h5-16H,17-18H2,1-4H3
InChIKey
PSOXOVKYGWBTPB-UHFFFAOYSA-N
PubChem Compound ID
46203250
PubChem Substance ID
96057330, 103749364, 120469921, 163364840, 238278471, 249019849, 252160954, 252166890
Target and Pathway
Target(s) Oxysterols receptor LXR-beta Target Info Antagonist [530809]
Oxysterols receptor LXR-alpha Target Info Antagonist [530809]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 543247(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8690).
Ref 530809Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6.

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