Drug General Information
Drug ID	D0Y7VJ
Former ID	DNC008173
Drug Name	L-NIL
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[546719]
Structure		Download 2D MOL 3D MOL
Formula	C8H17N3O2
Canonical SMILES	CC(=NCCCCC(C(=O)O)N)N.Cl
InChI	1S/C8H17N3O2.ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);1H
InChIKey	HJYWSATZDBEAOS-UHFFFAOYSA-N
PubChem Compound ID	2733506
Target and Pathway
Target(s)	Nitric oxide synthase, inducible	Target Info	Inhibitor	[529159]
	Nitric-oxide synthase, brain	Target Info	Inhibitor	[529159]
	Nitric-oxide synthase, endothelial	Target Info	Inhibitor	[529159]
BioCyc Pathway	Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway	Arginine biosynthesis
	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	HIF-1 signaling pathway
	Peroxisome
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Pathways in cancer
	Small cell lung cancerhsa00330:Arginine and proline metabolism
	Phagosome
	Circadian entrainment
	Long-term depression
	Salivary secretion
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)hsa00330:Arginine and proline metabolism
	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Platelet activation
	Estrogen signaling pathway
	Oxytocin signaling pathway
NetPath Pathway	IL1 Signaling Pathway
	IL2 Signaling PathwayNetPath_4:EGFR1 Signaling PathwayNetPath_8:Wnt Signaling Pathway
PANTHER Pathway	CCKR signaling map STP00005:Angiogenesis
	Endothelin signaling pathway
	Interleukin signaling pathway
	PI3 kinase pathway
	VEGF signaling pathway
Pathway Interaction Database	IL12-mediated signaling events
	Alpha9 beta1 integrin signaling events
	ATF-2 transcription factor network
	IL23-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
	HIF-1-alpha transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Thromboxane A2 receptor signaling
	SHP2 signaling
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
PathWhiz Pathway	Arginine and Proline Metabolism
Reactome	ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	eNOS activation
	Nitric oxide stimulates guanylate cyclase
	VEGFR2 mediated vascular permeability
WikiPathways	Type II interferon signaling (IFNG)
	Spinal Cord Injury
	AGE/RAGE pathway
	Effects of Nitric OxideWP727:Monoamine Transport
	Myometrial Relaxation and Contraction Pathways
	Amyotrophic lateral sclerosis (ALS)
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Alzheimers Disease
	Effects of Nitric Oxide
	Serotonin Transporter ActivityWP554:ACE Inhibitor Pathway
	EGF/EGFR Signaling Pathway
	JAK/STAT
	Corticotropin-releasing hormone
	Endothelin Pathways
	Leptin signaling pathway
	Metabolism of nitric oxide
	Angiogenesis
References
Ref 546719	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009876)
Ref 529159	Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. Epub 2007 Oct 25.Discovery of a series of aminopiperidines as novel iNOS inhibitors.

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