| Drug General Information |
| Drug ID |
D0WB6P
|
| Former ID |
DNC010243
|
| Drug Name |
R-NORDULOXETINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H17NOS
|
| Canonical SMILES |
C1=CC=C2C(=C1)C=CC=C2OC(CCN)C3=CC=CS3
|
| InChI |
1S/C17H17NOS/c18-11-10-16(17-9-4-12-20-17)19-15-8-3-6-13-5-1-2-7-14(13)15/h1-9,12,16H,10-11,18H2/t16-/m1/s1
|
| InChIKey |
ZMXLKLOJDLMZFC-MRXNPFEDSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
|---|
| Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Serotonergic synapsehsa04728:Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Amphetamine addiction
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Alcoholism
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
|
Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
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Parkinson disease
|
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Dopamine receptor mediated signaling pathway
|
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Pathway Interaction Database
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Alpha-synuclein signaling
|
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
|
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WikiPathways
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Monoamine Transport
|
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NRF2 pathway
|
|
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
|
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SIDS Susceptibility Pathways
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Synaptic Vesicle Pathway
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Serotonin Transporter ActivityWP727:Monoamine Transport
|
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Dopaminergic Neurogenesis
|
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Parkinsons Disease Pathway
|
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
|
|
Neurotransmitter Clearance In The Synaptic Cleft
|
| References |
| REF 1 | Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. Epub 2009 Aug 20.Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents fordepression. |
|---|
