Drug Information

Drug General Information
Drug ID
D0W8BJ
Former ID
DNC009205
Drug Name
Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529530]
Structure
Download
2D MOL

3D MOL
Formula
C16H17NO
Canonical SMILES
CC1=CC=CC=C1OC2CC(C3=CC=CC=C23)N
InChI
1S/C16H17NO/c1-11-6-2-5-9-15(11)18-16-10-14(17)12-7-3-4-8-13(12)16/h2-9,14,16H,10,17H2,1H3/t14-,16-/m0/s1
InChIKey
VQMGCAXPAOTPQE-HOCLYGCPSA-N
PubChem Compound ID
44560674
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [529530]
Sodium-dependent dopamine transporter Target Info Inhibitor [529530]
Sodium-dependent serotonin transporter Target Info Inhibitor [529530]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 529530Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. Epub 2008 May 20.Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
Ref 529530Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. Epub 2008 May 20.Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.