| Drug General Information |
| Drug ID |
D0V4RZ
|
| Former ID |
DNC008995
|
| Drug Name |
WAY-214950
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H13F5N2
|
| Canonical SMILES |
C1=CC=C(C(=C1)CN2C(=C3C=CC=C(C3=N2)C(F)(F)F)C4=CC=C(C=C<br />4)F)F
|
| InChI |
1S/C21H13F5N2/c22-15-10-8-13(9-11-15)20-16-5-3-6-17(21(24,25)26)19(16)27-28(20)12-14-4-1-2-7-18(14)23/h1-11H,12H2
|
| InChIKey |
NHSFDMDEDPAKNH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Oxysterols receptor LXR-beta |
Target Info |
Inhibitor |
[1]
|
|---|
| Pregnane X receptor |
Target Info |
Inhibitor |
[1]
|
| Oxysterols receptor LXR-alpha |
Target Info |
Inhibitor |
[1]
|
| mRNA of glucocorticoid receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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PPAR signaling pathway
|
|
Non-alcoholic fatty liver disease (NAFLD)
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Hepatitis Chsa04080:Neuroactive ligand-receptor interaction
|
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NetPath Pathway
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IL2 Signaling Pathway
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TCR Signaling Pathway
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Pathway Interaction Database
|
RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptorsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Signaling events mediated by HDAC Class II
|
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FOXA2 and FOXA3 transcription factor networks
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Glucocorticoid receptor regulatory network
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Regulation of Androgen receptor activity
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AP-1 transcription factor network
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Reactome
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Nuclear Receptor transcription pathwayR-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
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WikiPathways
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SREBP signalling
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Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
|
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Nuclear Receptors Meta-Pathway
|
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Pregnane X Receptor pathway
|
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Drug Induction of Bile Acid Pathway
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PPAR Alpha Pathway
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Liver X Receptor Pathway
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Adipogenesis
|
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SREBF and miR33 in cholesterol and lipid homeostasis
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Nuclear ReceptorsWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
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SIDS Susceptibility Pathways
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Endoderm Differentiation
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
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Circadian Clock
|
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Nuclear Receptors
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| References |
| REF 1 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. |
|---|
