Drug General Information
Drug ID	D0V0YM
Former ID	DIB015871
Drug Name	MK-5596
Synonyms	CB1 inverse agonists (obesity), Merck
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Investigative	[543877]
Company	Merck Research Laboratories
Structure		Download 2D MOL 3D MOL
Formula	C27H23Cl3N4O2
Canonical SMILES	c1c([nH]nc1C(=O)N[C@H]1c2cc(c3ccc(cc3)Cl)c(nc2OC(C)(C)C<br />1)c1ccc(cc1Cl)Cl)C
PubChem Compound ID	24871527
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Agonist	[543877]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 543877	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).
Ref 543877	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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