Drug Information
Drug General Information | |||||
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Drug ID |
D0T1FR
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Former ID |
DNC008302
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Drug Name |
Cis-2-aminocyclohexylcarbamoylphosphonic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529297] | ||
Structure |
Download2D MOL |
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Formula |
C7H15N2O4P
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Canonical SMILES |
C1CCC(C(C1)N)NC(=O)P(=O)(O)O
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InChI |
1S/C7H15N2O4P/c8-5-3-1-2-4-6(5)9-7(10)14(11,12)13/h5-6H,1-4,8H2,(H,9,10)(H2,11,12,13)/t5-,6+/m0/s1
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InChIKey |
XHCXISPZIHYKQD-NTSWFWBYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | 72 kDa type IV collagenase | Target Info | Inhibitor | [529297] | |
PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
Pathway Interaction Database | LPA receptor mediated events | ||||
Plasma membrane estrogen receptor signaling | |||||
Osteopontin-mediated events | |||||
Validated transcriptional targets of AP1 family members Fra1 and Fra2 | |||||
Angiopoietin receptor Tie2-mediated signaling | |||||
Direct p53 effectors | |||||
amb2 Integrin signaling | |||||
ATF-2 transcription factor network | |||||
FOXM1 transcription factor network | |||||
Regulation of nuclear beta catenin signaling and target gene transcription | |||||
Syndecan-2-mediated signaling events | |||||
References | |||||
Ref 529297 | J Med Chem. 2008 Mar 13;51(5):1406-14. Epub 2008 Feb 8.Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastaticmatrix metalloproteinase-2 selective inhibitor--synthesis and pharmacodynamic and pharmacokinetic analysis. | ||||
Ref 529297 | J Med Chem. 2008 Mar 13;51(5):1406-14. Epub 2008 Feb 8.Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastaticmatrix metalloproteinase-2 selective inhibitor--synthesis and pharmacodynamic and pharmacokinetic analysis. |
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