Drug Information

Drug General Information
Drug ID
D0S7ZQ
Former ID
DNC009854
Drug Name
4'-Methoxy-5,3'-dipropyl-biphenyl-2ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530176]
Structure
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2D MOL

3D MOL
Formula
C19H24O2
Canonical SMILES
CCCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)OC)CCC
InChI
1S/C19H24O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h8-13,20H,4-7H2,1-3H3
InChIKey
HFEJJSAHPYKAPW-UHFFFAOYSA-N
PubChem Compound ID
45267389
Target and Pathway
Target(s) mRNA of human 5-lipoxygenase Target Info Inhibitor [530176]
Prostaglandin G/H synthase 1 Target Info Inhibitor [530176]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosishsa00590:Arachidonic acid metabolism
Platelet activation
NetPath Pathway IL4 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
Phase 1 - Functionalization of compounds
Selenium Micronutrient Network
References
Ref 530176Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. Epub 2009 May 18.Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.
Ref 530176Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. Epub 2009 May 18.Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.

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