| Drug General Information |
| Drug ID |
D0S4DT
|
| Former ID |
DIB021159
|
| Drug Name |
vinburnine
|
| Synonyms |
eburnamonine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H22N2O
|
| InChI |
InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1
|
| InChIKey |
WYJAPUKIYAZSEM-MOPGFXCFSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
11341, 457665, 8141186, 8149858, 8194490, 10321289, 11335586, 11360825, 11363273, 11365835, 11368397, 11372476, 11374241, 11376559, 11407193, 11458362, 11460274, 11461797, 11466635, 11467755, 11485283, 11486469, 11489320, 11491014, 11492566, 11494193, 14898141, 16085526, 26652298, 26680063, 29204089, 43127578, 47216711, 47440186, 47515255, 47588935, 47959666, 47959667, 48035041, 48110392, 48184937, 49698581, 50063097, 50957982, 56463657, 57318066, 61212461, 85787855, 85789394, 88785574
|
| Target and Pathway |
| Target(s) |
Muscarinic receptor |
Target Info |
Modulator (allosteric modulator) |
[2]
|
|---|
| Muscarinic acetylcholine receptor M3 |
Target Info |
Modulator (allosteric modulator) |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PI3K-Akt signaling pathway
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
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Regulation of actin cytoskeleton
|
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Insulin secretion
|
|
Salivary secretion
|
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Gastric acid secretion
|
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Pancreatic secretion
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
PathWhiz Pathway
|
Muscle/Heart ContractionPW000565:Gastric Acid Production
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
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Acetylcholine regulates insulin secretion
|
|
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
|
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Regulation of Actin Cytoskeleton
|
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GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Secretion of Hydrochloric Acid in Parietal Cells
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GPCR ligand binding
|
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GPCR downstream signalingWP58:Monoamine GPCRs
|
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Integration of energy metabolism
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 345). |
|---|
| REF 2 | Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. |
|---|
