Drug Information
Drug General Information | |||||
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Drug ID |
D0RG3O
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Former ID |
DAP000377
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Drug Name |
Atropine
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Synonyms |
Anaspaz; Atropair; Atropen; Atropin; Atropina; Atropinol; Atropt; Atrosulf; Belladenal; Cytospaz; Eyesules; Hyoscyamine; Minims; Tropanol; Urised; Atropin [German]; Atropina [Italian]; Atropine Care; Atropine [BAN]; Atropinium cation; Hyoscyamine sulfate; Isopto Atropine; Minims Atropine; Tropine tropate; Troyl tropate; OR22908; A-Tropine; Atropen (TN); Atropin-flexiolen; Atropine (USP); Bellergal-S; D1-hyoscyamine; DL-Tropyl tropate; Dl-Hyoscyamine; Dl-Tropyltropate; I-Tropine; Isopto-atropine; Lomotil (TN); NP-010662; Neo-Diophen; Ocu-Tropine; Protamine & Atropine; Tropic acid, ester with tropine; Atropinium(1+); Tropan-3alpha-ol; Tropan-3beta-ol; Tropine, tropate (ester); Atropine Sulfate S.O.P.; Tropic acid, 3-alpha-tropanyl ester; DL-Tropanyl 2-hydroxy-1-phenylpropionate; Beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; Beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; Tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; Tropine (+/-)-tropate; Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; B eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate; Endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; (+,-)-Tropyl tropate; (+-)-atropine; (+-)-hyoscyamine; (+/-)-Atropine; (+/-)-Hyoscyamine; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane; (3-exo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester); 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); 1alphaH,5alphaH-Tropan-3alpha-ol; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); 1alphaH,5alphaH-Tropan-3beta-ol; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; 8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate
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Drug Type |
Small molecular drug
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Therapeutic Class |
Antiarrhythmic Agents
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Company |
Pfizer Pharmaceuticals
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Structure |
Download2D MOL |
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Formula |
C17H23NO3
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InChI |
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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InChIKey |
RKUNBYITZUJHSG-SPUOUPEWSA-N
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CAS Number |
CAS 51-55-8
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PubChem Compound ID | |||||
PubChem Substance ID |
4651, 814306, 841226, 7837579, 7847181, 7978742, 8144950, 10258016, 11533003, 16376693, 24890401, 24890659, 26754302, 29215197, 33498346, 36511844, 46476231, 46507540, 47359794, 48253833, 48413242, 48415591, 49857189, 53789078, 56313665, 56422449, 57352393, 75150730, 85788924, 85856317, 92308692, 93576972, 95156767, 104098724, 104169991, 104171350, 111677788, 113474904, 117475976, 118260686, 121362578, 124558762, 124799783, 124883031, 124883032, 124883033, 124883034, 129143706, 131408727, 134337687
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ChEBI ID |
ChEBI:16684
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SuperDrug ATC ID |
A03BA01; S01FA01
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SuperDrug CAS ID |
cas=000051558
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Target and Pathway | |||||
Target(s) | Muscarinic acetylcholine receptor M5 | Target Info | Antagonist | [535437], [537455], [537469], [537749] | |
References | |||||
Ref 534497 | Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and noncompetitive effects. Mol Pharmacol. 1997 Nov;52(5):886-95. | ||||
Ref 538234 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071295. | ||||
Ref 540179 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 320). | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
Ref 535437 | The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction. Nippon Hinyokika Gakkai Zasshi. 2002 Mar;93(3):427-34. | ||||
Ref 537455 | Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R412-20. Epub 2009 Jun 10. | ||||
Ref 537469 | Additive Protective Effects of Donepezil and Nicotine Against Salsolinol-Induced Cytotoxicity in SH-SY5Y Cells. Neurotox Res. 2009 Mar 20. | ||||
Ref 537749 | The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85. |
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