Drug General Information
Drug ID
D0RG3O
Former ID
DAP000377
Drug Name
Atropine
Synonyms
Anaspaz; Atropair; Atropen; Atropin; Atropina; Atropinol; Atropt; Atrosulf; Belladenal; Cytospaz; Eyesules; Hyoscyamine; Minims; Tropanol; Urised; Atropin [German]; Atropina [Italian]; Atropine Care; Atropine [BAN]; Atropinium cation; Hyoscyamine sulfate; Isopto Atropine; Minims Atropine; Tropine tropate; Troyl tropate; OR22908; A-Tropine; Atropen (TN); Atropin-flexiolen; Atropine (USP); Bellergal-S; D1-hyoscyamine; DL-Tropyl tropate; Dl-Hyoscyamine; Dl-Tropyltropate; I-Tropine; Isopto-atropine; Lomotil (TN); NP-010662; Neo-Diophen; Ocu-Tropine; Protamine & Atropine; Tropic acid, ester with tropine; Atropinium(1+); Tropan-3alpha-ol; Tropan-3beta-ol; Tropine, tropate (ester); Atropine Sulfate S.O.P.; Tropic acid, 3-alpha-tropanyl ester; DL-Tropanyl 2-hydroxy-1-phenylpropionate; Beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; Beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; Tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; Tropine (+/-)-tropate; Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; B eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate; Endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; (+,-)-Tropyl tropate; (+-)-atropine; (+-)-hyoscyamine; (+/-)-Atropine; (+/-)-Hyoscyamine; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane; (3-exo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester); 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); 1alphaH,5alphaH-Tropan-3alpha-ol; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); 1alphaH,5alphaH-Tropan-3beta-ol; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; 8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate
Drug Type
Small molecular drug
Indication Organophosphate poisoning [ICD9: 989.3; ICD10:T60.0] Approved [538234], [540179]
Poison intoxication [ICD10:T36-T50] Phase 1 [534497], [540179], [551871]
Therapeutic Class
Antiarrhythmic Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C17H23NO3
InChI
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
InChIKey
RKUNBYITZUJHSG-SPUOUPEWSA-N
CAS Number
CAS 51-55-8
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:16684
SuperDrug ATC ID
A03BA01; S01FA01
SuperDrug CAS ID
cas=000051558
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [535437], [537455], [537469], [537749]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 534497Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and noncompetitive effects. Mol Pharmacol. 1997 Nov;52(5):886-95.
Ref 538234FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071295.
Ref 540179(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 320).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535437The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction. Nippon Hinyokika Gakkai Zasshi. 2002 Mar;93(3):427-34.
Ref 537455Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R412-20. Epub 2009 Jun 10.
Ref 537469Additive Protective Effects of Donepezil and Nicotine Against Salsolinol-Induced Cytotoxicity in SH-SY5Y Cells. Neurotox Res. 2009 Mar 20.
Ref 537749The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.