| Drug General Information |
| Drug ID |
D0R2JE
|
| Former ID |
DNC012616
|
| Drug Name |
N-methoxyquinuclidine-3-carboximidoyl chloride
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H15ClN2O
|
| Canonical SMILES |
CON=C(C1CN2CCC1CC2)Cl
|
| InChI |
1S/C9H15ClN2O/c1-13-11-9(10)8-6-12-4-2-7(8)3-5-12/h7-8H,2-6H2,1H3/b11-9-
|
| InChIKey |
NJVYTBKHLPNMEV-LUAWRHEFSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
|---|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M5 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M4 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeleton
|
|
Insulin secretion
|
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Salivary secretion
|
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Gastric acid secretion
|
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Pancreatic secretionhsa04020:Calcium signaling pathway
|
|
cAMP signaling pathway
|
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PI3K-Akt signaling pathway
|
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
|
Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
PathWhiz Pathway
|
Gastric Acid ProductionPW000564:Muscle/Heart Contraction
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
Acetylcholine regulates insulin secretion
|
|
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
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Regulation of Actin Cytoskeleton
|
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GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Integration of energy metabolism
|
|
GPCR ligand binding
|
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GPCR downstream signaling
|
|
GPCRs, OtherWP58:Monoamine GPCRs
|
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Secretion of Hydrochloric Acid in Parietal Cells
|
|
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
| References |
| REF 1 | A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). |
|---|
