Drug General Information
Drug ID
D0P1FJ
Former ID
DNC000245
Drug Name
Aprophen
Drug Type
Small molecular drug
Indication Discovery agent Investigative [536212], [537749]
Structure
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2D MOL

3D MOL

Formula
C21H27NO2
Canonical SMILES
CCN(CC)CCOC(=O)C(C)(C1=CC=CC=C1)C2=CC=CC=C2
InChI
1S/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3
InChIKey
DIDYGLSKVUKRRP-UHFFFAOYSA-N
CAS Number
CAS 3563-01-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [536212], [537749]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536212M1 muscarinic antagonists interact with sigma recognition sites. Life Sci. 1991;49(17):1229-35.
Ref 537749The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.
Ref 536212M1 muscarinic antagonists interact with sigma recognition sites. Life Sci. 1991;49(17):1229-35.
Ref 537749The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.

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