Drug General Information
Drug ID
D0OK5I
Former ID
DAP000836
Drug Name
Tridihexethyl
Synonyms
Pathilon; Propethonum; (3-cyclohexyl-3-hydroxy-3-phenylpropyl)-triethylazanium; 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium
Drug Type
Small molecular drug
Indication Acquired nystagmus [ICD9: 379.5; ICD10:H55] Approved [538420]
Therapeutic Class
Anticholinergic Agents
Structure
Download
2D MOL

3D MOL

Formula
C21H36NO+
Canonical SMILES
CC[N+](CC)(CC)CCC(C1CCCCC1)(C2=CC=CC=C2)O
InChI
1S/C21H36NO/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3/q+1
InChIKey
NPRHVSBSZMAEIN-UHFFFAOYSA-N
CAS Number
CAS 60-49-1
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:9701
SuperDrug ATC ID
A03AB08
SuperDrug CAS ID
cas=000060491
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Binder [537342]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538420FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009489.
Ref 537342Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41.

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