Drug Information

Drug General Information
Drug ID
D0O6GN
Former ID
DNC002639
Drug Name
Mdl 101,146
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Terminated [546375]
Structure
Download
2D MOL

3D MOL
Formula
C29H37F5N4O6
Canonical SMILES
CC(C)C(C(=O)C(C(F)(F)F)(F)F)NC(=O)C1CCCN1C(=O)C(C(C)C)N<br />C(=O)C2=CC=C(C=C2)C(=O)N3CCOCC3
InChI
1S/C29H37F5N4O6/c1-16(2)21(23(39)28(30,31)29(32,33)34)35-25(41)20-6-5-11-38(20)27(43)22(17(3)4)36-24(40)18-7-9-19(10-8-18)26(42)37-12-14-44-15-13-37/h7-10,16-17,20-22H,5-6,11-15H2,1-4H3,(H,35,41)(H,36,40)/t20-,21-,22-/m0/s1
InChIKey
XQAMVCHQGHAELT-FKBYEOEOSA-N
CAS Number
CAS 149859-17-6
PubChem Compound ID
5289347
PubChem Substance ID
7890427, 11041550, 14863293, 14964517, 39321564, 46530872, 79640221, 103242042, 103954289, 113874126, 172649466, 198958460, 198979047
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [551393]
Elastase 1 Target Info Inhibitor [551393]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 546375Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007771)
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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