Drug Information

Drug General Information
Drug ID
D0O6BD
Former ID
DIB021171
Drug Name
VU0090157
Synonyms
cyclopentyl 1,6-dimethyl-4-(6-nitrobenzo[d][1,3]-dioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540228]
Structure
Download
2D MOL
Formula
C19H21N3O7
InChI
InChI=1S/C19H21N3O7/c1-10-16(18(23)29-11-5-3-4-6-11)17(20-19(24)21(10)2)12-7-14-15(28-9-27-14)8-13(12)22(25)26/h7-8,11,17H,3-6,9H2,1-2H3,(H,20,24)
InChIKey
GUFKDOZSNUQIAS-UHFFFAOYSA-N
PubChem Compound ID
2882724
PubChem Substance ID
3426025, 5333434, 7996361, 8106321, 10099607, 11188618, 17471027, 24331437, 26082557, 40848589, 47559938, 57728341, 78416115, 89224594, 96079280, 106180916, 111488281, 126153346, 170178843, 178100302, 215678199
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [529833]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540228(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3259).
Ref 529833Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol. 2009 Mar;75(3):577-88.

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