Drug Information

Drug General Information
Drug ID
D0O0OP
Former ID
DIB018187
Drug Name
[18F](R,R)-quinuclidinyl-4-fluoromethyl-benzilate
Synonyms
(R,R)-quinuclidinyl-4-[18F]-fluoromethyl-benzilate; (R,R)-quinuclidinyl-4-[18F]-fluoromethylbenzilate(PET ligand); [18F]-FMeQNB; (R,R)-[18F]-FMeQNB
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540239]
Structure
Download
2D MOL
Formula
C22H24FNO3
InChI
InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20-,22+/m0/s1/i23-1
InChIKey
WYNSCFORRAXQPA-IFWCHYDGSA-N
PubChem Compound ID
73755039
PubChem Substance ID
178100316
Target and Pathway
Target(s) Muscarinic receptor Target Info Antagonist [534477]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540239(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3275).
Ref 534477In vivo muscarinic binding selectivity of (R,S)- and (R,R)-[18F]-fluoromethyl QNB. Bioorg Med Chem. 1997 Aug;5(8):1555-67.

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