Drug General Information
Drug ID	D0J3BY
Former ID	DIB007694
Drug Name	Pimagedine HCl
Drug Type	Small molecular drug
Indication	Diabetic kidney disease [ICD10:E11.22]		Phase 2/3	[546189]
Company	Synvista Therapeutics
Structure		Download 2D MOL 3D MOL
Formula	CH7ClN4
Canonical SMILES	Cl.NNC(=N)N
InChI	1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChIKey	UBDZFAGVPPMTIT-UHFFFAOYSA-N
PubChem Compound ID	16017
Target and Pathway
Target(s)	Nitric oxide synthase, inducible	Target Info	Inhibitor	[529604]
BioCyc Pathway	Citrulline-nitric oxide cycle
KEGG Pathway	Arginine biosynthesis
	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	HIF-1 signaling pathway
	Peroxisome
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Pathways in cancer
	Small cell lung cancer
NetPath Pathway	IL1 Signaling Pathway
	IL2 Signaling Pathway
Pathway Interaction Database	IL12-mediated signaling events
	Alpha9 beta1 integrin signaling events
	ATF-2 transcription factor network
	IL23-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
	HIF-1-alpha transcription factor network
Reactome	ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclase
WikiPathways	Type II interferon signaling (IFNG)
	Spinal Cord Injury
	AGE/RAGE pathway
	Effects of Nitric Oxide
References
Ref 546189	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006816)
Ref 529604	Nitric oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory impairment during acute hypobaric hypoxia. Brain Res. 2008 Sep 16;1230:138-49.

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