Drug Information

Drug General Information
Drug ID
D0J2CR
Former ID
DNC000405
Drug Name
CGP 20712A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540814]
Structure
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2D MOL

3D MOL
Formula
C23H25F3N4O5
InChI
InChI=1S/C23H25F3N4O5/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33)
InChIKey
GKJZEKSHCJELPL-UHFFFAOYSA-N
CAS Number
CAS 15866-90-7
PubChem Compound ID
2685
PubChem Substance ID
5658896, 7978902, 8151743, 15010298, 26752033, 29221842, 47885606, 47959974, 48035347, 48110668, 50065245, 50104693, 53789928, 56413034, 57321399, 80652687, 85209005, 90341539, 103119314, 103197993, 104301307, 117569411, 124749654, 126407428, 127966555, 135650066, 136350836, 162916709, 163882654, 178633620, 179149534, 179499469, 224867632, 236154470
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [537882]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 540814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 541).
Ref 537882Distribution of beta 1- and beta 2-adrenoceptor subtypes in various mouse tissues. Neurosci Lett. 1993 Sep 17;160(1):96-100.

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