Drug General Information
Drug ID	D0J2AE
Former ID	DNC004910
Drug Name	3-Amino-benzenesulfonamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527654]
Structure		Download 2D MOL 3D MOL
Formula	C6H8N2O2S
Canonical SMILES	C1=CC(=CC(=C1)S(=O)(=O)N)N
InChI	1S/C6H8N2O2S/c7-5-2-1-3-6(4-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
InChIKey	JPVKCHIPRSQDKL-UHFFFAOYSA-N
PubChem Compound ID	7377
Target and Pathway
Target(s)	Carbonic anhydrase	Target Info	Inhibitor	[527292]
	Carbonic anhydrase IV	Target Info	Inhibitor	[527415]
	Carbonic anhydrase XIV	Target Info	Inhibitor	[527654]
	Carbonic anhydrase IX	Target Info	Inhibitor	[527654]
	Carbonic anhydrase XII	Target Info	Inhibitor	[527654]
	Carbonic anhydrase II	Target Info	Inhibitor	[527415]
KEGG Pathway	Nitrogen metabolism
	Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor network
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 527654	Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
Ref 527292	Bioorg Med Chem Lett. 2004 Dec 20;14(24):6001-6.Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
Ref 527415	Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
Ref 527654	Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.

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