Drug General Information
Drug ID	D0IJ7O
Former ID	DNC000928
Drug Name	Metastat
Drug Type	Small molecular drug
Indication	Acne vulgaris [ICD9: 706.1; ICD10:L70.0]		Phase 1	[521425], [527241]
Structure		Download 2D MOL 3D MOL
Formula	C19H17NO7
CAS Number	CAS 15866-90-7
PubChem Compound ID	9820748
Target and Pathway
Target(s)	72 kDa type IV collagenase	Target Info	Inhibitor	[535550]
KEGG Pathway	Leukocyte transendothelial migration
	GnRH signaling pathway
	Estrogen signaling pathway
	Pathways in cancer
	Proteoglycans in cancer
	Bladder cancer
NetPath Pathway	Leptin Signaling Pathway
	TCR Signaling Pathway
	ID Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
Pathway Interaction Database	LPA receptor mediated events
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Direct p53 effectors
	amb2 Integrin signaling
	ATF-2 transcription factor network
	FOXM1 transcription factor network
	Regulation of nuclear beta catenin signaling and target gene transcription
	Syndecan-2-mediated signaling events
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	EPH-ephrin mediated repulsion of cells
WikiPathways	Activation of Matrix Metalloproteinases
	AGE/RAGE pathway
	Matrix Metalloproteinases
References
Ref 521425	ClinicalTrials.gov (NCT00001683) A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer. U.S. National Institutes of Health.
Ref 527241	A phase I and pharmacokinetic study of Col-3 (Metastat), an oral tetracycline derivative with potent matrix metalloproteinase and antitumor properties. Clin Cancer Res. 2004 Oct 1;10(19):6512-21.
Ref 535550	Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002 Sep;2(9):657-72.

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