Drug General Information
Drug ID	D0IB6Y
Former ID	DNC009685
Drug Name	2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529955]
Structure		Download 2D MOL 3D MOL
Formula	C12H17NO2
Canonical SMILES	COC1=CC=C(C=C1)C2CCC(O2)CN
InChI	1S/C12H17NO2/c1-14-10-4-2-9(3-5-10)12-7-6-11(8-13)15-12/h2-5,11-12H,6-8,13H2,1H3
InChIKey	SUAFTJAVJHXARK-UHFFFAOYSA-N
PubChem Compound ID	11658526
Target and Pathway
Target(s)	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[529955]
	Sodium-dependent serotonin transporter	Target Info	Inhibitor	[529955]
	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[529955]
KEGG Pathway	Serotonergic synapsehsa04728:Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
	5HT2 type receptor mediated signaling pathway
	5HT3 type receptor mediated signaling pathway
	5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
	SIDS Susceptibility Pathways
	Synaptic Vesicle Pathway
	Serotonin Transporter ActivityWP727:Monoamine Transport
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 529955	Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. Epub 2009 Jan 15.2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.
Ref 529955	Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. Epub 2009 Jan 15.2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.

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